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BMS 433796
😃Good
Catalog No. T14690Cas No. 935525-13-6
Alias BMS-299897, BMS-289948
BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity in a transgenic mouse model of Alzheimer's disease.
BMS 433796
😃Good
Purity: 99.17%
Catalog No. T14690Alias BMS-299897, BMS-289948Cas No. 935525-13-6
BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity in a transgenic mouse model of Alzheimer's disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 665 € | 8-10 weeks | |
| 5 mg | 1.710 € | 8-10 weeks |
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Purity:99.17%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity in a transgenic mouse model of Alzheimer's disease. |
| Targets&IC50 | [3H]-IN973:1.2 nM, Aβ40:0.8 nM, Aβ42:0.4 nM |
| In vitro | BMS-433796 causes a concentration-dependent decrease in [3H]IN973 binding, with an IC50 value of 1.2 nM, which is very similar to the IC50 values for the inhibition of Aβ40 (0.8 nM) and Aβ42 (0.4 nM) in human embryonic kidney cells overexpressing the Swedish mutation of APP[1]. |
| In vivo | Characterized in pharmacokinetic studies in male Sprague-Dawley rats, BMS-433796 shows low clearance with a total body clearance of 5.2±0.82 mL/min/kg (means±SEM; n=3) following a 10-minute intravenous infusion at 2.3 μmol/kg in PEG-400. The apparent terminal elimination half-life is 4.6±0.48 h. Upon oral administration of a PEG-400 suspension at 35 μmol/kg, BMS-433796 exhibits an oral bioavailability of 31% with prolonged absorption. BMS-433796 demonstrates satisfactory metabolic stability in human liver microsomal preparations and is not an inhibitor of human CYPs (IC50>100 μM)[2]. The reduction of brain Aβ40 is dose-dependent upon administering BMS-433796, with an ED50 value of 2.4 mg/kg[1]. |
| Alias | BMS-299897, BMS-289948 |
| Molecular Weight | 430.4 |
| Formula | C21H20F2N4O4 |
| Cas No. | 935525-13-6 |
| Smiles | N(C([C@@H](NC([C@@H](O)C1=CC(F)=CC(F)=C1)=O)C)=O)[C@H]2C=3C(C=NN(C)C2=O)=CC=CC3 |
| Relative Density. | 1.42 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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